B-lactams and processes for their preparation and use

Details B-lactams and processes for their preparation and use B-lactams and processes for their preparation and use

C - Chemistry, Metallurgy

07

D

260/104.3, 260/1

C07D 499/70 (2006.01) C07D 501/24 (2006.01)

Patent

CA 1072079

Abstract 7-[.alpha.-(Imidarolidin-2-on-1-carbonylamido)acet- amido]-3-methylcaph-3-em-4-carboxylic acids and 6-[.alpha.- (imidazolidin-2-on-1-carbonylamido)acetamido]penicillanic acids, substituted in the 3-position of the imidazolidinone ring with cyclic structure and on the .alpha.-carbon atom of the acetamido bridge with a phenyl, thienyl, cyclohexenyl or cyclohexadiemyl group, and their salts, are prepared by acylation of an .alpha.-aminopenicillin or .alpha.-aminocephaloaporin, or, in the case of some cephalosporin derivatives, by treat- ment of the corresponding 3-acetoxymethylcephem with a mucleophilic reactant. The compounds, of which 7-[.alpha.-(3- cyclopropylimidezolidin-2-on-1-ylcarbonylamino)phenyl- acetamido]-3-(1-methyltetrazol-5-ylthiomethyl)ceph-3-em-4- carboxylic acid and .alpha.-[3-(fur-3-yl)imidazolidin-2-on-1-ylcar- boxyamino]benzylpenicillin are representative examples, are antibacterial agents.

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