B7-1-specific ligands, and their use for the induction of t...

Details B7-1-specific ligands, and their use for the induction of t... B7-1-specific ligands, and their use for the induction of t...

C - Chemistry, Metallurgy

12

N

C12N 5/16 (2006.01) A61K 31/445 (2006.01) A61K 31/57 (2006.01) A61K 38/13 (2006.01) A61K 39/395 (2006.01) A61P 37/06 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/12 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2183680

Anti-B7-1 antibodies or other B7-1 ligands may be used to prevent or treat a T-cell-mediated immune system disease in a patient or to induce antigen-specific tolerance. The anti-B7-1 antibodies may be used to cause T cell anergy, treat allograft transplant rejection, treat graft versus host disease, and prevent or treat rheumatoid arthritis. An immunosuppressive agent is co-administered with the antibody.

On peut utiliser des anticorps anti B7-1 ou d'autres ligands de l'antigène B7-1 pour prévenir ou traiter une maladie du système immunitaire provoquée chez un patient par les lymphocytes T, ou pour induire une tolérance vis-à-vis d'un antigène spécifique. Les anticorps anti-B7-1 peuvent être utilisés pour provoquer une anergie des lymphocytes T, pour lutter contre le rejet de greffes allogéniques, les incompatibilités greffe-patient et prévenir ou traiter les polyarthrites rhumatoïdes. Un agent immunosuppresseur est administré en même temps que l'anticorps.

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