B7-binding molecules for treating immune diseases

Details B7-binding molecules for treating immune diseases B7-binding molecules for treating immune diseases

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 31/445 (2006.01) A61K 31/57 (2006.01) A61K 38/13 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2292415

The present invention relates to molecules, such as diabodies, tri- and tetravalent antibodies and small antigen binding peptides, which can cross- link or cross-react with the costimulatory molecules B7.1 and B7.2 expressed on professional antigen presenting cells (APCs) leading to the inhibition of antigen-specific T cell activation. The present invention also concerns methods to produce these molecules and use of these molecules to treat diseases, such as transplant rejection, graft versus host disease (GVHD), allergy and autoimmune diseases, where antigen-specific T cell activation is pathogenic.

La présente invention concerne des molécules telles que des dianticorps (anticorps à double spécificité), des anticorps tri- et tétravalents et de petits peptides de liaison de l'antigène pouvant effectuer une liaison croisée ou une réaction croisée avec les molécules co-activatrices B7.1 et B7.2 exprimées sur des cellules de présentation de l'antigène professionnelles (APC) provoquant ainsi l'inhibition d'une activation de lymphocytes T spécifiques de l'antigène. La présente invention concerne également des méthodes de production de ces molécules et d'utilisation de ces molécules dans le traitement d'affections telles que le rejet de greffe, la réaction du greffon contre l'hôte (GVHD), les affections allergiques et autoimmunes, dans lesquelles l'activation de lymphocytes T spécifiques de l'antigène est pathogène.

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