B7 family member zb7h6 and related compositions and methods

Details B7 family member zb7h6 and related compositions and methods B7 family member zb7h6 and related compositions and methods

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2697992

Disclosed is a newly identified B7 family member, zB7H6, which functions as a counter-receptor for the NK cell triggering receptor, NKp30. Methods and compositions for modulating NKp30- mediated NK cell activity based on the interaction of zB7H6 with NKp30, as well as related screening methods, are also disclosed. Further disclosed are anti-zB7H6 antibodies as well as antibody-drug conjugates comprising an anti-zB7H6 antibody conjugated to a therapeutic agent, including methods for using such antibodies and antibody-drug conjugates to exert therapeutic effects against zB7H6-expressing cells.

L'invention concerne un membre nouvellement identifié de la famille B7, zB7H6, qui fonctionne comme un contre-récepteur du récepteur de déclenchement de cellule NK, NKp30. L'invention concerne également des procédés et des compositions pour moduler l'activité cellulaire NK induite par NKp30 en fonction de l'interaction de zB7H6 avec NKp30, ainsi que des procédés de criblage associés. L'invention concerne en outre des anticorps anti-zB7H6 et des conjugués anticorps-médicaments comprenant un anticorps anti-zB7H6 conjugué à un agent thérapeutique, ainsi que des procédés d'utilisation de ces anticorps et de ces conjugués anticorps-médicaments afin d'exercer des effets thérapeutiques contre les cellules exprimant le zB7H6.

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