B7-related nucleic acids and polypeptides useful for...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/62 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2449890

The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T- cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL2 and splice variants thereof. The present invention further provides isolated B7-related polypeptides that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for diagnostic applications and the immunomodulation of a human or animal subject.

La présente invention concerne des acides nucléiques codant des facteurs associés à B7 modulant l'activation de cellules de réponse immune ou inflammatoire, telles que des lymphocytes T. L'invention concerne également des vecteurs d'expression ainsi que des constructions de fusion contenant des acides nucléiques codant des polypeptides associés à B7, notamment BSL2 ainsi que leurs variants d'épissage. La présente invention concerne aussi des polypeptides associés à B7 isolés, des protéines de fusion isolées comprenant des polypeptides associés à B7, ainsi que des anticorps réagissant spécifiquement avec des polypeptides associés à B7, ou des parties de ceux-ci. De plus, la présente invention concerne des dosages utilisant des acides nucléiques, des polypeptides ou des peptides associés à B7. La présente invention concerne en outre des compositions d'acides nucléiques, de polypeptides, de protéines de fusion ou d'anticorps associés à B7 lesquelles sont utiles dans des applications diagnostiques et pour l'immunomodulation d'un sujet humain ou animal.

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