C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2362126
Novel polypeptides which comprise a receptor-ligand pair involved in T-cell activation are disclosed. Nucleic acid molecules encoding said polypeptides, and vectors and host cells for expressing same are also disclosed. The polypeptides, or agonists and antagonists thereof, are used to treat T-cell mediated disorders.
L'invention porte sur de nouveaux polypeptides comprenant une paire de récepteurs-ligands impliqués dans l'activation des lymphocytes T. L'invention porte également sur des molécules d'acide nucléique codant ces polypeptides et sur des vecteurs et des cellules hôtes utilisés dans l'expression de ces polypeptides. Les polypeptides ou leurs agonistes ou antagonistes sont utilisés pour traiter des pathologies induites par les lymphocytes T.
Amgen Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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