Backbone modified oligonucleotide analogs

Details Backbone modified oligonucleotide analogs Backbone modified oligonucleotide analogs

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C07D 405/04 (2006.01) C07D 405/14 (2006.01) C07F 7/18 (2006.01) C07H 19/04 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01) C07H 19/16 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2103464

2103464 9220823 PCTABS00017 Therapeutic oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. Replacement of phosphorodiester inter-sugar linkages found in wild type oligomers with four atom linking groups forms unique di- and poly-nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.

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