Bacteria attenuated by a non-reverting mutation in each of...

Details Bacteria attenuated by a non-reverting mutation in each of... Bacteria attenuated by a non-reverting mutation in each of...

C - Chemistry, Metallurgy

12

N

C12N 15/03 (2006.01) A61K 39/108 (2006.01) C12N 1/20 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2323576

The invention provides a bacterium attenuated by a non-reverting mutation in each of the aroC gene, the ompF gene and the ompC gene. The bacterium is useful as a vaccine. The bacterium may, for example, be an attenuated strain of E.coli useful in vaccination against diarrhoea.

L'invention concerne une bactérie atténuée par mutation irréversible de chacun des gènes aroC, ompF et ompC. Cette bactérie est utile comme vaccin. Elle peut, par exemple, être une souche atténuée de E. coli utile comme vaccin contre la diarrhée.

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