Bacteria-mediated gene modulation via microrna machinery

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/63 (2006.01) C12N 15/113 (2010.01) A61K 31/7105 (2006.01) A61K 35/74 (2006.01) C12N 1/21 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2728571

The present invention provides a method of synthesizing, processing, and/or delivering miRNA or its precursors to eukaryotic cells using bacteria, preferably non-pathogenic or therapeutic strains of bacteria, to effect gene modulation in eukaryotic cells.

La présente invention concerne un procédé de synthèse, traitement et/ou délivrance de miARN ou ses précurseurs à des cellules eucaryotes en utilisant des bactéries, de préférence des souches de bactéries non pathogènes ou thérapeutiques, pour réaliser une modulation de gènes dans des cellules eucaryotes.

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