Bacteria strains having a high anti-inflammatory activity

Details Bacteria strains having a high anti-inflammatory activity Bacteria strains having a high anti-inflammatory activity

A - Human Necessities

61

K

A61K 35/74 (2006.01) A61P 1/00 (2006.01)

Patent

CA 2754300

The present invention relates to probiotic bacteria strains having a high anti- inflammatory activity. The present invention relates to bacteria strains as strongly inducers of Interleukin-10 (IL-10) production. In particular, the present invention relates to the anti-inflammatory activity shown by said bacteria strains due to its enhancement of IL-10 production in peripheral blood mononuclear cells, with on the other hand a low capability to stimulate the production of the pro-inflammatory 11-12, thus leading to a high IL-10/IL-12 ratio. Further, the present invention relates to the use of at least one bacterium strain for the preparation of a composition for the prevention or treatment of the inflammatory bowel diseases (IBD) and irritable bowel syndrome (IBS). Finally, the present invention relates to food products, such as probiotic dietary supplements containing at least one probiotic bacterium strain, as an active ingredient.

La présente invention concerne des souches bactériennes probiotiques ayant une grande activité anti-inflammatoire. La présente invention concerne des souches bactériennes en tant qu'inducteurs forts de la production d'interleukine 10 (IL-10). La présente invention concerne notamment l'activité anti-inflammatoire présentée par lesdites souches bactériennes en raison de leur amélioration de la production d'IL-10 dans les cellules mononucléaires de sang périphérique, avec en revanche une faible capacité à stimuler la production d'IL-12 pro-inflammatoire, conduisant ainsi à un rapport élevé d'IL-10/IL-12. La présente invention concerne en outre l'utilisation d'au moins une souche bactérienne destinée à la préparation d'une composition pour la prévention ou le traitement d'affections abdominales inflammatoires (IBD) et du syndrome du côlon irritable. La présente invention concerne finalement des produits alimentaires, tels que des suppléments alimentaires probiotiques contenant au moins une souche bactérienne probiotique, en tant que principe actif.

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