Bacterial antigens and uses thereof

Details Bacterial antigens and uses thereof Bacterial antigens and uses thereof

C - Chemistry, Metallurgy

12

P

C12P 19/04 (2006.01) A61K 38/14 (2006.01) A61K 39/02 (2006.01) A61K 39/095 (2006.01) A61K 39/102 (2006.01) A61P 31/04 (2006.01) C12N 9/24 (2006.01)

Patent

CA 2630404

Novel enzymes, processes and antigenic structures useful in producing vaccines and compounds useful in combating gram-negative bacteria are described. Enzymes were isolated from the slime mould Dictyostelium discoideum and used to specifically degrade lipopolysaccharide (LPS). Enzymatic degradation permits residues of the LPS molecule, including immunogenic epitopes of the core oligosaccharide portion of the LPS, to remain unmodified during this enzymatic removal of fatty acids from the lipid A region of the LPS molecule.

L'invention concerne de nouvelles enzymes, de nouveaux procédés et de nouvelles structures antigéniques utilisés dans la production de vaccins et de composés servant à combattre des bactéries Gram négative. Les enzymes sont isolées de la myxomycoseDictyostelium discoideum et utilisées pour dégrader spécifiquement un lipopolysaccharide (LPS). La dégradation enzymatique permet que des résidus de la molécule LPS, y compris des épitopes immunogéniques de la partie centrale oligosaccharide du LPS, demeurent non modifiés pendant l'élimination enzymatique des acides gras de la région lipidique A de la molécule LPS.

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