Bacterial antigens, antibodies, vaccines, and methods of...

Details Bacterial antigens, antibodies, vaccines, and methods of... Bacterial antigens, antibodies, vaccines, and methods of...

C - Chemistry, Metallurgy

12

P

167/135, 167/139

C12P 19/04 (2006.01) A61K 39/09 (2006.01) C07H 3/06 (2006.01) C08B 37/00 (2006.01) C12N 9/38 (2006.01) G01N 33/569 (2006.01)

Patent

CA 1305918

BACTERIAL ANTIGENS, ANTIBODIES, VACCINES, AND METHODS OF MANUFACTURE Abstract of the Disclosure Antigens and vaccines containing purified oligomers (1-50 units) of the repeating pentasaccharide unit of type III Group B Stretococcus (III GBS) polysaccharide capsule. Methods of making the antigen by recovering polysaccharide from cultured III GBS or medium and digesting the polysaccharide with a specific endo-B-galactosidase. Enzymatic cleavage of bacterial polysaccharide to make purified oligomers. A purified trypsin-resistant C surface protein, m.w. about 14,000 and vaccine. Passive immunization using the above vaccines. Immunoassays for GBS immunodeterminants or anti-GBS antibodies.

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