Bacterial antigens, antibodies, vaccines, and methods of...

Details Bacterial antigens, antibodies, vaccines, and methods of... Bacterial antigens, antibodies, vaccines, and methods of...

C - Chemistry, Metallurgy

07

K

167/135, 167/199

C07K 14/315 (2006.01) A61K 39/09 (2006.01) G01N 33/569 (2006.01)

Patent

CA 1339187

Antigens and vaccines containing purified oligomers (1-50 units) of the repeating pentasaccharide unit of type III Group B Stretococcus (III GBS) polysaccharide capsule. Methods of making the antigen by recovering polysaccharide from cultured III GBS or medium and digesting the polysaccharide with a specific endo-B-galactosidase. Enzymatic cleavage of bacterial polysaccharide to make purified oligomers. A purified trypsin-resistant C surface protein, m.w. about 14,000 and vaccine. Passive immunization using the above vaccines. Immunoassays for GBS immunodeterminants or anti-GBS antibodies.

616431

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