Bacterial carboxypeptidase cpg2 variants and their use in...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/57 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C12N 9/48 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) C12P 13/00 (2006.01)

Patent

CA 2409679

The present invention relates to bacterial carboxypeptidases for use in gene directed prodrug therapy, in particular for use in the treatment of disease, including tumours. Specifically, the invention relates to modified bacterial carboxypeptidases which have enhanced catalytic activity.

La présente invention concerne des carboxypeptidases bactériennes destinées à être utilisées en thérapie par promédicaments ayant une action sur les gènes, en particulier pour traiter certaines maladies, notamment les tumeurs. Particulièrement, cette invention concerne des carboxypeptidases bactériennes modifiées présentant une activité catalytique accrue.

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