Bacterial delivery of biologically active polypeptides

Details Bacterial delivery of biologically active polypeptides Bacterial delivery of biologically active polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01)

Patent

CA 2620508

The present invention relates to methods for the delivery of biologically active polypeptides to a subject by colonising non-pathogenic Gram negative bacteria. Also provided by this invention are methods of treating or preventing diseases by administering colonising Gram negative bacteria that express one or more biologically active polypeptides. The colonising non- pathogenic Gram negative bacteria may be administered in pharmaceutical formulations.

La présente invention concerne des méthodes d'administration de polypeptides biologiquement actifs à un sujet par des bactéries Gram-négatives non pathogènes colonisantes. L~invention concerne aussi des méthodes pour traiter ou prévenir des maladies par l~administration de bactéries Gram-négatives colonisantes exprimant un ou plusieurs polypeptides biologiquement actifs. Les bactéries Gram-négatives non pathogènes colonisantes peuvent être administrées sous forme de formules pharmaceutiques.

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