C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) C12N 5/00 (2006.01) C12N 5/02 (2006.01) C12N 13/00 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2593715
Disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, methods of improving vaccine efficacy, and methods of treating an infection. Also disclosed are methods of promoting tumor rejection, treating cancer, modulating autoimmunity and inhibiting allergen-induced hypersensitivity in subjects. The methods include contacting an NKT cell with a bacterial glycolipid complexed with a CD1 molecule to activate the NKT cell. The bacterial glycolipid may be derived from a member of the Class Alphaproteobacteria.
L'invention porte: sur des méthodes d'activation de cellules NKT, sur des méthodes de stimulation d'une réponse immune chez un sujet, sur des méthodes d'amélioration de l'efficacité d'un vaccin, sur des méthodes de traitement d'une infection, sur des méthodes: favorisant le rejet des tumeurs, de traitement du cancer, de modulation de l'auto-immunité, et d'inhibition de l'hypersensibilité de sujets. Lesdites méthodes consistent à mettre en contact une cellule NKT avec un glycolipide bactérien complexé avec une molécule CD1 pour activer la cellule NKT. Le glycolipide bactérien peut dériver d'un élément de la classe Alphaprotéobactérie
Bendelac Albert
Savage Paul B.
Teyton Luc
Brigham Young University
The Scripps Research Institute
The University Of Chicago
Torys Llp
LandOfFree
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