Bacterial host strains

Details Bacterial host strains Bacterial host strains

C - Chemistry, Metallurgy

12

N

C12N 1/21 (2006.01) C07K 14/705 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2430249

An E. coli strain is described that is deficient in chromosomal degP and prc encoding protease DegP and Prc, respectively, and harbors a mutant spr gene that encodes a protein that suppresses growth phenotypes exhibited by strains harboring prc mutants. Preferably, the strain comprises nucleic acid encoding a polypeptide heterologous to the strain, so that a heterologous polypeptide can be produced therefrom.

L'invention concerne une souche E. coli déficiente en degP et prc chromosomiques codant respectivement pour les protéases DegP et Prc. Cette souche héberge un gène spr mutant codant pour une protéine supprimant les phénotypes de croissance présentés par les souches hébergeant les mutants prc. De préférence, ladite souche comprend un acide nucléique codant pour un polypeptide hétérologue à la souche, d'où la possibilité de produire un polypeptide hétérologue correspondant.

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