Bacterial inhibition with an oligosaccharide compound

Details Bacterial inhibition with an oligosaccharide compound Bacterial inhibition with an oligosaccharide compound

A - Human Necessities

61

K

A61K 31/715 (2006.01) A61K 9/12 (2006.01) C07H 3/06 (2006.01)

Patent

CA 2224102

The present invention is directed to a method of treating respiratory infections caused by a bacteria selected from the group consisting of S. pneumoniae, H. influenzae, H. parainfluenzae, Burkholderia (Pseudomonas cepacia) and a mixture thereof, by administering a binding inhibiting effective amount of the compound of formula (I), where R1 is H, (.beta.- 1)GalNAc-, SO3B (where B is H or a cation) or a sialic acid of formula (II), where R6, R7, R8, and R10 are each independently H, C1-6 acyl, lactyl, C1-6 alkyl, sulfate, phosphate, anhydro, a sialic acid of formula (II), (.alpha.- 1)Fuc, (.beta.-1)Glc or (.beta.-1)Gal; R9 is NH-C1-6 acyl, glycolylamido, amino or hydroxyl; and A is H or a cation; R2 is H or (.alpha.-1)Fuc-; R3 and R4 are each independently OH or NHAc; R5 is H, SO3B (where B is H or a cation) or a sialic acid of formula (II) as defined above; and Y is a chemical bond or a linking group; Z is H or a multivalent support; m is 0 or 1; and p is an integer of 1 to 1,000; and a pharmaceutical composition containing same.

L'invention concerne une méthode de traitement d'infections des voies respiratoires causées par une bactérie sélectionnée dans un groupe englobant les S. pneumoniae, H. influenzae, H. parainfluenzae, Burkholderia (Pseudomonas cepacia) et un mélange de ceux-ci, consistant à administrer une quantité efficace pour l'inhibition des liaisons d'un composé de formule (I), dans laquelle R¿1? est H, (.beta.-1)GalNAc-, SO¿3?B (où B est H ou un cation), ou un acide sialique de formule (II), dans laquelle R¿6?, R¿7?, R¿8?, et R¿10? désignent, chacun indépendamment, H, acyle en C¿1-6?, lactyle, alkyle en C¿1-6?, sulfate, phosphate, anhydro, un acide sialique de formule (II), (.alpha.-1)Fuc, (.beta.-1)Glc ou (.beta.-1)Gal; R¿9? est NH-acyle en C¿1-6?, glycolylamido, amino ou hydroxyle, et A est H ou un cation; R¿2? est H ou (.alpha.-1)Fuc-; R¿3? et R¿4? représentent, chacun indépendamment, OH ou NHAc; R¿5? est H, SO¿3?B (où B est H ou un cation) ou un acide sialique de formule (II) tel que précédemment défini; Y est une liaison chimique ou un groupe de liaison; Z est H ou un support multivalent; m est égal à 0 ou 1, et p est un nombre entier compris entre 1 et 1000. L'invention concerne également une composition pharmaceutique contenant les composés précités.

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