Bacterial mass production of paclitaxel

Details Bacterial mass production of paclitaxel Bacterial mass production of paclitaxel

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) C12P 17/02 (2006.01)

Patent

CA 2220081

The present invention relates to a biologically pure culture of a novel bacteria of genus Erwinia, which is isolated from Taxus canadensis, and wherein the bacteria of genus Erwinia taxi is characterized by the production of paclitaxel and related taxanes in a fermentative or respiratory type of metabolism from simple semi-synthetic or synthetic culture media. Also, the present invention relates to a method of bacterial mass production of paclitaxel and related taxanes which comprises the steps of: a) culturing the bacteria of genus Erwinia taxi of the present invention in a growth-supporting nutrient medium capable of promoting growth and reproduction of the bacteria, and wherein the culturing is effected for a time sufficient to allow production of paclitaxel and related taxanes; and b) isolating the produced paclitaxel and related taxanes from the culturing medium of step a).

Culture biologiquement pure d'une nouvelle bactérie du genre Erwinia, isolée de Taxus canadensis, la bactérie du genre Erwinia taxi étant caractérisée par la production de paclitaxel et de taxanes associés dans un métabolisme de type fermentatif ou respiratoire à partir de milieux de culture simples semi-synthétiques ou synthétiques. La présente invention concerne également un procédé de production en masse de paclitaxel et de taxanes associés qui consiste (a) à mettre en culture la bactérie du genre Erwinia taxi de la présente invention dans un milieu nutritif propice à la croissance, capable de promouvoir la croissance et la reproduction de la bactérie, la culture étant effectuée pendant une durée suffisante pour permettre la production de paclitaxel et de taxanes associés, et (b) à isoler le paclitaxel et les taxanes associés produits du milieu de culture de l'étape (a).

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