Bacterial receptor structures

Details Bacterial receptor structures Bacterial receptor structures

C - Chemistry, Metallurgy

07

K

C07K 14/31 (2006.01) C07K 19/00 (2006.01) C12N 15/09 (2006.01) C12P 21/00 (2006.01) C40B 30/00 (2006.01)

Patent

CA 2181042

Novel proteins obtainable by mutagenesis of surface-exposed amino acids of domains of natural bacterial receptors, said proteins being obtained without substantial loss of basic structure and stability of said natural bacterial receptors; proteins which have been selected from a protein library embodying a repertoire of said novel proteins; and methods for the manufacture of artificial bacterial receptor structures.

L'invention concerne de nouvelles protéines pouvant être obtenues par mutagenèse d'acides aminés à surface exposée de domaines de récepteurs bactériens naturels, lesdites protéines étant obtenues sans perte substantielle de la structure basique et de la stabilité desdits récepteurs bactériens naturels. L'invention concerne également des protéines sélectionnées dans une bibliothèque de protéines regroupant un répertoire desdites nouvelles protéines, ainsi que des procédés de préparation de structures bactériennes réceptrices artificielles.

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