Bacterial superantigen vaccines

Details Bacterial superantigen vaccines Bacterial superantigen vaccines

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/085 (2006.01) A61K 39/44 (2006.01) C07K 14/00 (2006.01) C07K 14/31 (2006.01) C07K 14/315 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2338184

The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and a n appropriate immune response is produced. The attenuated superantigen toxins are shown to protect animals against challenge with wild type toxin. Methods of producing and using the altered superantigen toxins are described.

L'invention concerne des vaccins à toxines superantigènes génétiquement atténuées, c'est-à-dire modifiées de manière à éliminer les attributs de superantigène, mais en n'empêchant ni la reconnaissance effective des superantigènes ni l'élaboration d'une réponse immunitaire appropriée. Il est apparu que les toxines considérées protégeaient les animaux contre la provocation issue des toxines de type sauvage. L'invention concerne également des procédés relatifs à la production et à l'utilisation des toxines en question.

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