Bacterial vaccines comprising auxotrophic, attenuated...

Details Bacterial vaccines comprising auxotrophic, attenuated... Bacterial vaccines comprising auxotrophic, attenuated...

A - Human Necessities

61

K

A61K 39/02 (2006.01) C07H 21/04 (2006.01) C07K 14/16 (2006.01) C07K 14/195 (2006.01) C12P 21/04 (2006.01) C12P 21/06 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2309790

The invention is directed to the use of an auxotrophic attenuated strain of Listeria monocytogenes which expresses an antigen, wherein said auxotrphic attenuated strain comprises a mutation in both a dal gene and a dat gene of said Listeria monocytogenes, for eliciting a T cell immune response to said antigen in a mammal. This invention is also directed to a vaccine.

L'invention concerne des mutants auxotrophes atténués de Listeria, ainsi que des procédés servant à les mettre en application sous forme de vaccins.

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