Bacterial vector

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/63 (2006.01) A61K 38/00 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2586081

The present invention relates to a combination of compounds for introducing nucleic acids and/or protein into animal cells, tissue, organs or organisms in vitro, extracorporal, or in vivo. This combination comprises preparations suitable for administration to an animal or human for medical purposes, comprising as one component a bacterial vector genetically manipulated to contain nucleic acid sequences comprising a transgene, and a second component for the subsequent transcription, possibly translation of the transgene by controlled induction of bacterial vector as it is present within the animal or human.

L'invention concerne une combinaison de composés pour l'introduction d'acides nucléiques et/ou une protéine dans des cellules, des tissus, des organes ou des organismes d'animaux in vitro, de manière extra-corporelle ou in vivo. Cette combinaison comprend des préparations convenant à l'administration à un animal ou un humain à des fins médicales, constitué d'un premier composant se présentant sous la forme d'un vecteur bactérien manipulé génétiquement de manière qu'il contienne des séquences nucléotidiques comprenant un transgène, et un second composant pour la transcription ultérieure, éventuellement la traduction du transgène par induction contrôlée du vecteur bactérien tel qu'il est présent dans l'animal ou l'humain.

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