Bactericidal/permeability-increasing protein:...

Details Bactericidal/permeability-increasing protein:... Bactericidal/permeability-increasing protein:...

G - Physics

01

N

G01N 33/68 (2006.01) C07K 1/00 (2006.01) C07K 14/47 (2006.01) G01N 33/53 (2006.01) G06F 17/50 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2293999

The present invention solves the three-dimensional structure of BPI and thereby provides atomic coordinates of BPI from the analysis of x-ray diffraction patterns of sufficiently high resolution for three-dimensional structure determination of the protein, as well as methods for rational drug design, based on using amino acid sequence data and/or x-ray diffraction data provided on computer readable media, as analyzed on a computer system having suitable computer algorithms; and atomic coordinates are provided yielding structural information on related proteins, including the lipid binding and lipid transport protein family that includes BPI, LBP, CETP and PLTP.

La présente invention permet de déterminer la structure tridimensionnelle de la BPI (protéine bactéricide/augmentant la perméabilité) et, par conséquent, de fournir les coordonnées atomiques de celle-ci sur la base de l'analyse des diagrammes de diffraction des rayons X de résolution suffisamment haute pour effectuer l'analyse de la structure tridimensionnelle de la protéine. L'invention concerne également des procédés d'élaboration rationnelle de substances thérapeutiques, fondés sur l'utilisation de données relatives à des séquences d'acides aminés et/ou à la diffraction des rayons X disponibles sur des supports lisibles par un ordinateur, telles qu'analysées sur un système informatique ayant des algorithmes informatiques appropriés. L'invention concerne en outre des coordonnées atomiques fournissant des informations structurelles sur les protéines associées, y compris la famille de protéines de liaison de lipides et de transport de lipides, notamment la BPI, la LBP, la CETP et la PLTP.

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