Bactericide against streptococcus mutans and streptococcus...

A - Human Necessities – 61 – K

Patent

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A61K 38/16 (2006.01) A61P 1/02 (2006.01) A61P 31/04 (2006.01) C12N 9/24 (2006.01) C12N 15/56 (2006.01)

Patent

CA 2550013

It is intended to provide an enzyme having a bacteriolytic effect on bacteria causative of tooth caries, methods of treating or preventing tooth caries with the use of this enzyme and so on. The above-described enzyme, which is a bacteriolytic enzyme produced by Streptococcus mutans, has a substrate specificity of selectively lysing Streptococcus sobrinus. By using this enzyme, therefore, it is possible to selectively remove a cariogenic bacterium in the oral cavity or reducing the bacterial count, thereby exerting an effect of preventing tooth caries.

L'invention concerne une enzyme qui exerce une action bactériolytique envers des bactéries qui provoquent des caries dentaires, ainsi que des procédés pour traiter ou prévenir des caries dentaires au moyen de cette enzyme. L'enzyme bactériolytique selon l'invention est produite par Streptococcus mutans, et présente une spécificité de substrat par lyse sélective de Streptococcus sobrinus. Ainsi, l'utilisation de cette enzyme permet de supprimer sélectivement une bactérie cariogène dans la cavité buccale ou de réduire la numération bactérienne, ce qui permet de prévenir les caries dentaires.

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