C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/33 (2006.01) A61K 9/72 (2006.01) A61K 35/76 (2006.01) A61K 47/26 (2006.01) A61P 31/04 (2006.01) C12N 7/00 (2006.01)
Patent
CA 2744909
A respirable composition for treatment of a bacterial infection includes one or more active bacteriophages in combination with a pharmaceutically acceptable respirable carrier. The composition includes a carbohydrate carrier, and is prepared as fine powder. In another aspect, bacteriophages are provided in a liquid carrier for administration by nebulization. In one aspect, the bacteriophages have anti-bacterial activity against one or more species or strains of Burkholderia cepacia complex (BCC) bacteria. The invention further relates to the use of a BCC bacteriophage to treat a BCC infection, in particular in an individual suffering from cystic fibrosis.
L'invention porte sur une composition inhalable pour le traitement d'une infection bactérienne comprenant un ou plusieurs bactériophages actifs en association avec un véhicule inhalable pharmaceutiquement acceptable. La composition comprend un véhicule glucidique et est préparée sous forme d'une poudre fine. Dans un autre aspect, des bactériophages sont fournis dans un véhicule liquide pour l'administration par nébulisation. Dans un aspect, les bactériophages ont une activité antibactérienne vis-à-vis d'une ou plusieurs espèces ou souches de bactéries complexes Burkholderia cepacia (BCC). L'invention porte en outre sur l'utilisation d'un bactériophage de BCC pour traiter une infection à BCC, en particulier chez un individu souffrant de mucoviscidose.
Dennis Jonathan J.
Finlay Warren H.
Lynch Karlene Heather
Orszanska Helena
Seed Kimberley D.
Dennis Jonathan J.
Finlay Warren H.
Lynch Karlene Heather
Orszanska Helena
Ridout & Maybee Llp
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