Bacteriophage having modified holin and uses thereof

Details Bacteriophage having modified holin and uses thereof Bacteriophage having modified holin and uses thereof

A - Human Necessities

01

N

A01N 63/00 (2006.01) A61K 35/76 (2006.01) C07K 14/01 (2006.01) C12N 7/00 (2006.01)

Patent

CA 2504331

The present invention features composition and methods for treating a bacterial infection using therapeutic bacteriophage having a modified holin gene. The modified holin inactivates the bacterial host prior to production of bacteriophage, so that the bacteriophage infection is non-productive, e.g., few or no bacteriophage are produced as a result of infection of the bacterial host. Thus, holin-modified bacteriophage invade the bacterial host, and cause inactivation of the bacterial host prior to production of a detectable or significant number of phage. Holin-modified phage inhibit the spread of bacterial infection without production of a significant or detectable number of phage progeny. By avoiding the release of phage progeny, the potential for generation of immune responses against the phage is reduced.

La présente invention se rapporte à une composition et à des méthodes permettant de traiter une infection bactérienne au moyen de bactériophages thérapeutiques possédant un gène holine modifié. La holine modifiée inactive l'hôte bactérien avant que des bactériophages en soient produits, de façon que l'infection par bactériophages soit non productive, autrement dit que peu ou pas de bactériophages soient produits à la suite de l'infection de l'hôte bactérien. Ainsi, les bactériophages à holine modifiée envahissent l'hôte bactérien, et provoquent l'inactivation de ce dernier avant de produire un nombre détectable ou important de phages. Les phages à holine modifiée inhibent la propagation de l'infection bactérienne sans produire une descendance importante ou détectable. En empêchant l'émission de ladite descendance de phages, on réduit les risques de génération d'une réponse immunitaire dirigée contre les phages.

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