Bacteriophage with enhanced lytic activity

Details Bacteriophage with enhanced lytic activity Bacteriophage with enhanced lytic activity

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2699451

This invention encompasses for an isolated Bacillus phage AP50 that has one or more nucleotide substitutions in the phage genome, whereby the one or more nucleotide substitutions increase lytic activity of the phage. In addition, the invention encompasses for proteins expressed by the phages, compositions containing the proteins and/or the phage as well as methods of using the Bacillus phage AP50 to test for the presence of B. anthracis.

L'invention concerne un phage bacille AP50 isolé qui comprend une ou plusieurs substitutions de nucléotide dans le génome du phage, la ou les substitutions de nucléotide dans le phage augmentant l'activité lytique du phage. L'invention concerne, en outre, des protéines exprimées par les phages, des compositions contenant ces protéines et/ou le phage ainsi que des procédés d'utilisation du phage bacille AP50 pour détecter la présence de B. anthracis.

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