C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/864 (2006.01)
Patent
CA 2694406
The present invention relates to production of proteins in insect cells whereby repeated coding sequences are used in baculoviral vectors. In particular the invention relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral rep proteins that increase the productivity of parvoviral vectors.
La présente invention porte sur la production de protéines dans des cellules d'insecte de sorte que des séquences codantes répétées sont utilisées dans des vecteurs baculoviraux. En particulier, l'invention porte sur la production de vecteurs parvoviraux qui peuvent être utilisés en thérapie génique et sur des perfectionnements de l'expression des protéines Rep virales qui augmentent la productivité de vecteurs parvoviraux.
Bakker Andrew Christian
Hermens Wilhelmus Theodorus Johannes Maria Christiaan
Amsterdam Molecular Therapeutics B.v.
Gowling Lafleur Henderson Llp
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