C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) C07K 14/01 (2006.01) C12N 7/00 (2006.01) C12N 15/01 (2006.01) C12N 15/10 (2006.01) C12N 15/34 (2006.01) C12N 15/866 (2006.01)
Patent
CA 2301179
A baculovirus artificial chromosome is disclosed which has the lef-8 gene inactivated. The baculovirus artificial chromosome allows the cloning and expression of heterologous genes in insect and mammalian cells without killing the host cells. Also disclosed is an infectious baculovirus comprising the artificial chromosome and a cell containing the chromosome. Also disclosed is an insect cell which expresses the LEF-8 gene in the absence of a baculovirus chromosome. Also disclosed is a method to express heterologous proteins in eukaryotic cells using the baculovirus artificial chromosome.
Cette invention concerne un chromosome artificiel de baculovirus dont le gène lef-8 n'est pas activé. Ce chromosome artificiel de baculovirus permet de cloner et d'exprimer des gènes hétérologues dans des cellules d'insectes et de mammifères sans tuer les cellules hôtes. Cette invention concerne également un baculovirus infectieux comprenant le chromosome artificiel, ainsi qu'une cellule contenant ce chromosome. Cette invention concerne en outre une cellule d'insecte qui exprime le gène LEF-8 en l'absence d'un chromosome de baculovirus. Cette invention concerne enfin un procédé permettant d'exprimer des protéines hétérologues dans des cellules eucaryotes à l'aide de ce chromosome artificiel de baculovirus.
Farrell Patrick J.
Hashimoto Yoshifumi
Iatrou Kostas
Marks & Clerk
University Technologies International Inc.
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