Baff mutants with at least one amino acid substitution and...

Details Baff mutants with at least one amino acid substitution and... Baff mutants with at least one amino acid substitution and...

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 38/00 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2523776

The invention relates to BAFF protein mutants carrying at least one amino acid substitution at one position having dominant negative antagonist activity, receptor antagonist activity and agonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the BAFF protein mutants in the treatment of BAFF or APRIL-related disorders.

L'invention concerne de nouvelles protéines présentant un antagoniste négatif dominant de BAFF, une activité agoniste et une activité antagoniste de récepteur, et des acides nucléiques codant ces protéines. L'invention concerne également l'utilisation de nouvelles protéines dans le traitement de troubles associés à BAFF ou à APRIL.

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