Bar1 secretion signal

Details Bar1 secretion signal Bar1 secretion signal

C - Chemistry, Metallurgy

12

N

195/1.2, 195/1.2

C12N 15/62 (2006.01) C07K 14/395 (2006.01) C07K 14/49 (2006.01) C07K 14/62 (2006.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12N 9/60 (2006.01) C12N 9/72 (2006.01) C12N 15/81 (2006.01) C12N 15/85 (2006.01)

Patent

CA 1314830

ABSTRACT The invention provides a DNA construct capable of being transformed into a yeast or mammalian cell for the secretion of heterologous proteins therefrom. The construct comprises a transcriptional promoter operably linked to a DNA sequence encoding a signal peptide, followed in reading frame by a second DNA sequenca encoding a portion of the BAR1 gene product, including at least a portion of the C-terminal domain and a heterologous protein or polypeptide. The invention may be used to express a variety of proteins including urokinase, insulin, platelst-derived growth factor and analogs thereof. The signal sequence and the sequence encoding a portion of the Barrier C- terminal region encode a hybrid secretory peptide which is then used to direct the secretion of heterologous proteins or polypeptides from host cells. The secretory peptide is subsequently cleaved from the heterologous protein.

579704

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