C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/62 (2006.01) A61K 31/515 (2006.01) C07D 409/06 (2006.01)
Patent
CA 2324584
The present invention relates to a barbituric acid derivative shown in formula (I) (wherein R or R1 independently represents a hydrogen atom, a susbstituted or not substituted alkyl group or alkenyl group of C1 - C15, a substituted or not substituted arylmethyl group, and substituted or not substituted aryl group, and R2 represents substituted or not substituted alkyl group or alkenyl group of C1 - C15, a substituted or not substituted arylmethyl group, and substituted or not substituted aryl group). The barbituric acid derivative of the present invention has a strong inhibiting activity to bone resorption and is useful as a preventive and therapeutic agent for diseases affecting bone and cartilage.
L'invention porte sur un dérivé de l'acide barbiturique de formule (I) dans laquelle: R ou R?1¿ représentent H, un groupe alkyle ou alcényle C¿1?-C¿15? substitué ou non, un groupe arylméthyle substitué ou non, ou un groupe aryle substitué ou non; et R?2¿ représente un groupe alkyle ou alcényle C¿1?-C¿15? substitué ou non, un groupe arylméthyle substitué ou non, ou un groupe aryle substitué ou non. Ce dérivé exerce une forte action inhibitrice sur la résorption osseuse et s'avère utile pour la prévention et le traitement de maladies affectant les os et les cartilages.
Sakai Kunikazu
Satoh Yusuke
Hoechst Marion Roussel
Robic
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