Barbituric acid derivatives with antimetastatic and...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 239/62 (2006.01) A61K 31/515 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2294259

The present invention relates to barbituric acid derivatives of general formula (I) wherein the meanings of R, n and A are disclosed in the claims. These compounds showed a marked activity as inhibitors of the metzincins and can be used as antitumor or antimetastatic agents.

La présente invention concerne des dérivés d'acide barbiturique de la formule générale (I), les significations de R, n et A étant précisées dans les revendications. Ces composés ont démontré une activité significative comme inhibiteurs des metzincines et peuvent s'utiliser comme agents antitumoraux ou antimétastatiques.

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