Barrier stent and use thereof

A - Human Necessities – 61 – F

Patent

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Details

A61F 2/06 (2006.01)

Patent

CA 2600924

The present invention relates to a vascular stent that includes an expandable stent defining an interior compartment, a first polymeric layer exposed to the interior compartment defined by the stent, the first layer comprising an agent that promotes re-endothelialization, an agent that inhibits thrombosis, or a combination thereof, and a second polymeric layer at least partially external of the stent, the second layer being adapted for contacting a vascular surface and being characterized by pores that are substantially impermeable to vascular smooth muscle cell migration. Method of making and using the vascular stent are also disclosed.

L'invention concerne un stent vasculaire comprenant un stent déployable qui définit un compartiment intérieur; une première couche polymère exposée au compartiment intérieur défini par le stent, ladite première couche comprenant un agent favorisant la réendothélialiation; un agent qui inhibe la thrombose ou une combinaison de celui-ci; et une seconde couche polymère au moins partiellement extérieure au stent, cette seconde couche étant conçue pour être en contact avec une surface vasculaire et étant caractérisée par des pores qui sont sensiblement imperméables à la migration cellulaire des muscles lisses. L'invention concerne également un procédé permettant de produire et d'utiliser le stent vasculaire.

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