Bartonella henselae virb operon and proteins encoded thereby

Details Bartonella henselae virb operon and proteins encoded thereby Bartonella henselae virb operon and proteins encoded thereby

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 31/711 (2006.01) A61K 39/02 (2006.01) C07K 14/195 (2006.01) G01N 33/53 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2414125

The present invention includes nucleic acids of the Bartonella henselae virB virulence operon and polypeptides encoded by the nucleic acids. The invention includes expression vectors containing the nucleic acids and transformed cell lines containing the expression vectors. The invention includes detection methods for B. henselae infection, and kits for performing these methods. The methods comprise detecting the nucleic acids or polypeptides of the invention, or antibodies against the polypeptides, in patient fluids. Also included in the invention are therapeutic compositions, such as vaccines, for treating Bartonella henselae infection. Furthermore, the invention includes antibodies against the polypeptides encoded by the B. henselae virB operon. Finally, the invention includes methods of producing polypeptides encoded by the B. henselae virB operon.

L'invention concerne des acides nucléiques de l'opéron de virulence virB de Bartonella henselae et des polypeptides codés par ces acides nucléiques. Elle concerne des vecteurs d'expression contenant lesdits acides nucléiques et des lignées cellulaires transformées contenant lesdits vecteurs d'expression. Elle concerne des méthodes de détection d'une infection induite par B. henselae, et des kits permettant de mettre ces méthodes en oeuvre. Lesdites méthodes consistent à détecter, dans les fluides d'un patient, les acides nucléiques, les polypeptides de l'invention, ou les anticorps agissant contre lesdits polypeptides. Elle concerne des compositions thérapeutiques, telles que des vaccins, permettant de traiter une infection induite par Bartonella henselae. Elle concerne des anticorps orientés contre les polypeptides codés par l'opéron virB de B. henselae. Elle concerne enfin des méthodes permettant de produire des polypeptides codés par l'opéron virB de B. henselae.

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