Base addition salts of omeprazole

C - Chemistry – Metallurgy – 07 – D

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167/119, 167/231

C07D 401/12 (2006.01) A61K 31/44 (2006.01)

Patent

CA 1264751

23940-461 Abstract There are disclosed novel salts of the compound known under the generic name omeprazole, having the formula Image (i) with Li+ , Na+ , K+ , Mg2+ , Ca2+ , Ti4+, N+(R1)4 or Image as cation, process for preparation thereof and pharmaceutical compositions containing such salts. The salts which exhibit improved storage stability than the neutral form of omeprazole are useful for inhibiting gastric acid secretion and for providing gastrointestinal cytoprotective effects in mammals and man.

448761

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