Base analogues

Details Base analogues Base analogues

C - Chemistry, Metallurgy

07

H

C07H 19/23 (2006.01) A61K 31/706 (2006.01) A61P 31/12 (2006.01) C07D 487/04 (2006.01) C07F 9/6561 (2006.01) C07H 21/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2412292

The present invention describes novel compounds of the formula (I) wherein Q is H or a sugar or a sugar analogue or a nucleic acid backbone or backbone analogue, Y=O, S, NR10, where R10 is H, alkyl alkenyl, alkynyl, X is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl or a combination thereof or, preferably, a reporter group. The novel compounds are suitable for incorporation in oligonucleotides and polynucleotides.

L'invention concerne de nouveaux composés de la formule (I) dans laquelle Q représente H, un sucre, un analogue de sucre, un squelette d'acide nucléique, ou un analogue de squelette ; Y=O, S, NR?10¿, où R?10¿ représente H, alkyle, alcényle, alcynyle ; X représente H, alkyle, alcényle, alcynyle, aryle, hétéroaryle, une combinaison de ceux-ci ou bien, de préférence, un groupe rapporteur. Ces nouveaux composés sont adaptés pour être incorporés aux oligonucléotides ou aux polynucléotides.

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