Base-detecting pore

Details Base-detecting pore Base-detecting pore

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2730068

The invention relates to a mutant .alpha.-hemolysin (.alpha.-HL) pore which is useful for detecting one or more nucleotides by stochastic sensing The pore is particularly useful for sequencing DNA or RNA A molecular adaptor that allows detection of the nucleotide(s) is covalently attached to the pore The pore is specifically modified to facilitate positioning of the adaptor and may be modified to facilitate covalent attachment

L'invention porte sur un pore d'a-hémolysine (a-HL) mutante utile pour détecter un ou plusieurs nucléotides par détection stochastique. Le pore est particulièrement utile pour le séquençage d'ADN ou d'ARN. Un adaptateur moléculaire qui permet la détection du ou des nucléotides est fixé de façon covalente au pore. Le pore est spécifiquement modifié pour faciliter le positionnement de l'adaptateur et peut être modifié pour faciliter la fixation covalente.

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