C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/279.2, 260/3
C07D 327/02 (2006.01) C07C 29/147 (2006.01) C07C 33/46 (2006.01) C07C 45/00 (2006.01) C07C 45/29 (2006.01) C07C 47/575 (2006.01) C07D 211/22 (2006.01) C07D 321/10 (2006.01) C07D 339/00 (2006.01) C07D 411/06 (2006.01)
Patent
CA 1186313
ABSTRACT OF THE DISCLOSURE: The invention comprises compounds and methods of preparation of a large area of basic derivatives of linearly condensed tricyclic systems formed by two external benzene nuclei and a central seven-membered ring with two chalcogen atoms as hetero atoms When both of the chalocogens are atoms of oxygen, we are dealing with derivatives of 11H- dibenzo(b,e)-1,4-dioxepin; when both of the chalcogens are sulfur atoms, we are dealing with derivatives of 11H-dibenzo (b,e)-1,4-dithiepin and in the case of the both possible combinations of atoms of oxygen and sulfur we are dealing with derivatives of 6H-dibenz(b,e)-1,4-oxathiepin and 11H- dibenz(b,f)-1,4-oxathiepin. Compounds according to the invention contain in molecules various types of aminoalkyl groups connected to the single carbon atom of the central ring which may be considered (dimethylaminomethyl, 2- dimethylaminoethyl, 2-methylaminoethyl, 3-dimethylaminopropyl, 3-methylaminopropyl, 3-piperidinopropyl, 1-methyl-3-piperidyl- methyl, 1-methyl 4-piperidyl. Some of the compounds according to the invention are substituted in the benzene rings with atoms of halogens, with methoxyl, trifluoromethyl, trifluoro- methylthio group. The invention includes not only the bases but also their salts with pharmaceutically acceptable acids. The invention includes also several methods for the prepara- tion of the compounds defined consisting in (a) construction of the whole molecules by cyclization of the diaryl ether or diaryl sulfide derivatives with a preformed side chain, (b) introduction of the side chains into the first synthesized tricyclic systems, (c) modification of the side chains in the amino group fragment, (d) selective oxidations to N-oxides, sulfoxides or sulfones. The compounds of the invention have mild or very intensive psychotropic activity and in agreement with their structures they are neuroleptics, tranquillizers and antidepressants.
398212
Dlabac Antonin
Metysova Jirina
Protiva Miroslav
Sindelar Karel
Robic Robic & Associes/associates
Spofa Spojene Podniky Pro Zdravotnickou Vyrobu
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