Basic ethers and process for the preparation thereof

C - Chemistry – Metallurgy – 07 – C

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C07C 251/58 (2006.01) A61K 31/15 (2006.01) A61K 31/33 (2006.01) C07D 207/08 (2006.01) C07D 295/088 (2006.01) C07D 295/108 (2006.01) C07D 317/58 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2121003

BASIC ETHERS AND PROCESS FOR THE PREPARATION THEREOF A B S T R A C T The invention relates to novel, pharmaceutically active basic ethers, a process for the preparation thereof and pharmaceutical compositions comprising the same. The invention also encompasses the use of the said basic ethers for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The new compounds according to the invention are characterized by general formula (I), wherein Image (I) R1 and R2 are independently hydrogen, halogen or C1-4 alkoxy, or together they represent a 3,4-methylenedioxy group, R stands for C1-8 alkyl, R3 represents hydrogen, C1-4 alkyl or hydroxy, A is a valency bond or a methylene group, R4 and R5 are independently hydrogen, C1-12 alkyl or C1-12 alkenyl, or - 2 - R4 and R5 form together with the adjacent nitrogen atom a 4- to 7-membered ring optionally comprising an oxygen, sulfur or a further nitrogen atom, which latter may carry a phenyl, benzyl or C1-4 alkyl substituent, and possess valuable antiulceric and anxiolytic activities, so they can be used to advantage in therapy.

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