C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/576.1
C07C 217/24 (2006.01) A61K 31/085 (2006.01) A61K 31/13 (2006.01) A61K 31/135 (2006.01) A61K 31/205 (2006.01) A61K 31/65 (2006.01) C07C 43/21 (2006.01) C07C 13/567 (2006.01)
Patent
CA 1148567
ABSTRACT OF THE DISCLOSURE: The invention relates to basic ethers of 7-oxo-7H- benzo[c]fluorene of the general formula (I): Image (I) wherein R1 is a hydrogen atom or a methyl or ethyl group and Z represents an omega-[N,N-dialkylamino]alkyl radical, and to their addition salts with pharmaceutically acceptable inorganic and organic acids. Also, the invention relates to a process for the production of the above identified compounds of the general formula I by aminoalkylation of 5-hydroxy-7-oxo-7H- benzo[c]fluorene and its correspondingly nuclear-substituted derivatives on the hydroxylic oxygen atom in the position 5. The compounds of the general formula I showed a markedly pro- nounced antineoplastic effect in animals with solid and ascitic transplantable tumors and two kinds of leukemias.
370028
Cernochova Slavjanka
Krepelka Jiri
Melka Milan
Pokorna Stanislava
Pujman Vojtech
Robic Robic & Associes/associates
Spofa Spojene Podniky Pro Zdravotnickou Vyrobu
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