C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/359.2, 260/2
C07D 311/22 (2006.01) C07D 211/22 (2006.01) C07D 223/04 (2006.01) C07D 295/084 (2006.01) C07D 295/092 (2006.01) C07D 311/30 (2006.01) C07D 311/32 (2006.01) C07D 311/36 (2006.01) C07D 311/38 (2006.01) C07D 311/58 (2006.01) C07D 311/60 (2006.01) C07D 405/12 (2006.01) C07D 493/04 (2006.01)
Patent
CA 1154444
ABSTRACT OF THE DISCLOSURE Basic ethers of the formula Image wherein Z is CH3-NR2-CH2CH2-CHR1-, (1-R2-3-piperidyl)- CHR3-, (1-R2-piperidyl)-CH2-CHR3- or 1-R2-3-R4- hexahydroazepinyl; R1 is cyclopropyl or Ar; R2 is H, alkyl of 1 - 4 C atoms, alkenyl of 2 - 4 C atoms, cycloalkylalkyl of 4 - 8 C atoms or benzyl; R3 is H or Ar; R4 is H or alkyl of 1 - 4 C atoms, Y is -O-CHQ1-CHQ2-CH2-, -O-CHQ1-CHQ2-CO-, -O-CQ1=CQ2-CO- or -CH2-CHQ1-CHQ2-CO-; Q1 and Q2 are independently each H, alkyl of 1 - 4 C atoms, cycloalkyl or alkylcycloalkyl each of 3 - 6 total C atoms or Ar; and Ar is phenyl or phenyl substituted by F, C1, alkoxy or alkylthio, each of 1 - 4 C atoms, methylenedioxy or CF3; with the proviso that when Z is (CH3)2N-CH2CH2-CHR1 in 7-position and Y is -O-C(C6H5)=CH-CO- or -O-C(C6H5)=C(CH3)-CO-, R1 is cyclo- propyl, or phenyl substituted by F, C1, alkoxy or alkylthio, each of 1 - 4 C atoms, methylenedioxy or CF3; or a physiologically acceptable acid addition salt thereof, have valuable pharmacological properties, e.g., are antidepressants.
366689
Hausberg Hans-Heinrich
Minck Klaus
Prucher Helmut
Seyfried Christoph
Uhl Jurgen
Borden Ladner Gervais Llp
Merck Patent Gesellschaft Mit Beschraenkter Haftung
LandOfFree
Basic ethers, pharmaceutical formulations containing them... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Basic ethers, pharmaceutical formulations containing them..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Basic ethers, pharmaceutical formulations containing them... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-36369