Basic oxime ethers and a process for preparing same

Details Basic oxime ethers and a process for preparing same Basic oxime ethers and a process for preparing same

C - Chemistry, Metallurgy

07

D

167/223, 167/273

C07D 295/12 (2006.01) A61K 31/15 (2006.01) C07D 295/088 (2006.01)

Patent

CA 1247103

ABSTRACT The invention relates to new basic oxime ethers of the general Formula (I) Image (I) and pharmaceutically acceptable acid addition salts thereof, a process for their preparation and pharma- ceutical compositions comprising the same. In the general Formula (I) A) if n is 4, A1) R stands for phenyl, A is trimethylene and R1 and R2 each stand for isopropyl or together with the adjacent nitrogen atom form a N-phenyl-piperazino group; or A2) R stands for phenyl, A is ethylene and R1 and R2 each stand for isopropyl; or A3) R stands for phenyl, A is -CH2-CH(CH3)- and R1 and R2 each stand for methyl; or A4) R stand for 4-chloro-phenyl, A is tri- methylene and R1 and R2 each represent isopropyl; or A5) R stands for 4-chloro-phenyl, A is ethylene and R1 and R2 each stand for methyl; or B) if n is 5, - 2 - B1) R stands for phenyl, A is ethylene and R1 and R2 are identical and each stand for methyl or isopropyl; or B2) R stands for phenyl, A is -CH2-CH(CH3)- and R1 and R2 are methyl; or B3) R stand for 3-chloro-phenyl, A is tri- methylene and R1 and R2 together with the adjacent nitrogen atom form a N-benzyl- piperazino group; or C) if n is 6, C1) R stands for phenyl, A is trimethylene and R1 and R2 each stand for methyl; or C2) R stands for phenyl, A is ethylene and R1 and R2 each stand for isopropyl; with the proviso that if n is 5 and R is phenyl, and A is ethylene and R1 and R2 each are isopropyl, the compound of the general Formula (I) is of Z,E con- figuration and in all the other cases the compound of the general Formula (I) is of E,E configuration. The compounds of the general Formula (I) can be used in therapy due to their narcosis potentiat- ing, analgesic and anitarrhytmial effect.

446931

Affiliated with

Also associated with

Rating

Basic oxime ethers and a process for preparing same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Basic oxime ethers and a process for preparing same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Basic oxime ethers and a process for preparing same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1313068