Basic thioethers

Details Basic thioethers Basic thioethers

C - Chemistry, Metallurgy

07

D

260/308, 260/390

C07D 333/76 (2006.01) C07D 233/60 (2006.01) C07D 295/084 (2006.01) C07D 295/096 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1118780

ABSTRACT OF THE DISCLOSURE Basic thioethers of the formula R-A-(CH2)n wherein R is p-R5-S-phenyl or 2-dibenzothienyl: A is -CHR3-CHR4-, -CR3(OH)-CHR4-, -CHR3-CR4(OH)- or -CR3=CR4-: Z is -NR1R2, 1-imidazolyl or 1,2,4-triazol- 1-yl: n is 1, 2 or 3: R1 and R2 are the same or different and each is H, alkyl of 1-4 carbon atoms or together form alkylene of 4-7 ring carbon atoms, or form oxapentamethylene; R3 and R4 are the same or different and each is H, alkyl of 1-4 carbon atoms or phenyl; R5 is an unsubstituted phenyl or benzyl group or a phenyl or benzyl group substituted with 1 or 2 of halogen, nitro, amino and/or alkoxy of 1-4 carbon atoms, alkyl of 1-6 carbon atoms, or cycloalkyl of 3-7 ring carbon atoms, with the proviso that R5 is alkyl of 1-6 carbon atoms, or cycloalkyl of 3-7 ring carbon atoms when A is -CHR3-CH2- and Z is 1-imidazolyl possess valuable pharmacological properties. MERCK 438

307658

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