C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/277.1, 260/2
C07D 401/02 (2006.01) C07D 217/22 (2006.01) C07D 295/04 (2006.01) C07D 471/10 (2006.01)
Patent
CA 1055026
ABSTRACT 1,4-Dihydro-2H-isoquinoline derivatives of the general formula 1 Image (1) in which R1 represents hydrogen or straight chain or branched alkyl of 1 to 6 atoms, R2 represents low molecular dialkylaminoalkyl, in which both al- kyl groups of the dialkylamino group together with the nitro- gen atom may also form a 5-, 6- or 7-membered saturated ring in which one carbon atom may be substituted by an oxygen atom, a sulfur atom or another nitrogen atom which may be substi- tuted by hydrogen, C1-C4-alkyl or phenyl, or R1 and R2to- gether may form a 5- or 6-membered saturated ring containing 1 nitrogen atom, R3 represents phenyl which may be mono- or di-substituted by halogen, nitro, amino sulfamoyl, or acylamino or alkyl each containing 1 to 4 carbon atoms, or pyridyl, R4 and R5, which may identical or different, represent hydrogen or al- koxy of 1 to 4 carbon atoms, and X represent oxygen or sulfur, their physiologically tolerated salts, process for preparing them. The compounds are active on the coronary circulation and are distinguished in particular by an- anti-arrhythmic action and may therefore, be used in the treatment of disorders of the heart rhythm.
211683
Kaiser Joachim
Kunstmann Rudolf
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