Basically substituted 3,4-dihydro-2h-isoquinolin-1-thiones...

Details Basically substituted 3,4-dihydro-2h-isoquinolin-1-thiones... Basically substituted 3,4-dihydro-2h-isoquinolin-1-thiones...

C - Chemistry, Metallurgy

07

D

260/277.1, 260/2

C07D 401/06 (2006.01) C07D 217/22 (2006.01) C07D 217/24 (2006.01) C07D 295/10 (2006.01) C07D 295/125 (2006.01)

Patent

CA 1055027

ABSTRACT this invention relates to 3,4-aihydro-2H-isoquinoline- l-ones of the formula (X) Image wherein X1 represents hydrogen, a saturated or unsaturated, sraight-chained or branched alkyl radical having 1 to 6 car- bon atoms or the phenyl radical, R2 represents a dialkylamino- alkyl radical of the formula Image wherein A represents a straight-chained or branched low mole- cular alkylene group and R5 and R6 are identical or different and represent straight-chained or branched, low molecular alkyl radicals and may form together with the nitrogen atom a 5-, 6- or 7-membered ring, wherein one of the hydrocarbons is substituted by a hetero atom which may be substituted with hydrogen, C1-C4 - alkyl or the phenyl radical, R3 and R4 are identical or dif- ferent and represent hydrogen or a lower alkoxy group having 1 to 4 carbon atoms, and the physiologically tolerable salts thereof. The compounds have an antiarrhythmic activity and are suitable for treating disturbances of cardiac rhythm.

233696

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