Basically substituted phenylacetonitriles, their preparation...

Details Basically substituted phenylacetonitriles, their preparation... Basically substituted phenylacetonitriles, their preparation...

C - Chemistry, Metallurgy

07

C

167/243, 167/251

C07C 255/58 (2006.01) A61K 31/275 (2006.01) C07D 317/60 (2006.01) C07D 319/08 (2006.01)

Patent

CA 1337991

Disclosed are basically substituted phenylacetonitriles Image where R1, R2 and R3 are identical or different and are each hydrogen, halogen, trifluoromethyl, C1-C4-alkyl, nitro or C1-C4-alkoxy, and two radicals in adjacent positi- ons may furthermore together form a methylenedioxy, ethy- lenedioxy, 1,3-dioxatetramethylene, propylene or butylene group, R4 is a saturated or unsaturated alkyl or cycloalkyl group of not more than 8 carbon atoms or phenyl, R5 is hydrogen or C1-C4-alkyl, R6 is a saturated or unsaturated hydrocarbon radical of 6 to 15 carbon atoms which may con- tain a ring, and n is 2, 3 or 4. These compounds are useful for the treatment of disorders, such as cardiovascular disorders, in particular coronary heart disease, vasospasms, cerebral ischemia, hypertension and circulatory shock. They can also be used for the prophylaxis and therapy of gastric and duodenal ulcers and asthmatic disorders.

554039

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