C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/242.4
C07D 473/06 (2006.01) C07D 473/08 (2006.01)
Patent
CA 1078379
ABSTRACT OF THE DISCLOSURE A xanthine derivative corresponding to the general formula T - Alk - NH - CH2 - CH(OH) - CH2 - O - Ar in which T represents a theophyllinyl-(7) or theobrominyl-(1) radical, Alk is a linear or branched alkylene group with 2 to 5 carbon atoms which may also be substituted by a hydroxy group and Ar represents a naphthyl radical, a phenyl radical, an indolyl radical, an indolyl radical substituted in at least one of the 2 and 3-positions by a C1-C4 alkyl group or a phenyl radical which is substituted by a C1-C4 alkyl group, a C1-C4 alkoxy group, a halogen atom, a C2-C6 alkenyl group, a C2-C6 alkenyloxy group, or a C2-C6 alkanoylamino group, or a pharmaceutically acceptable salt thereof. The xanthine deriva- tives show pharmacodynamic activity. In particular they block the .beta.-receptors of the adrenergic nervous system. For example they have an inhibiting action of the circulatory effects induced by isoprenalin [1-(2,3-dihydroxyphenyl)-2-isopropyl amino ethanol]. Accordingly, the compounds according to the invention are particularly suitable for treating the following diseases: tacharrhythmia, angina pectoris, vegetative heart-function disorders, arterial or essential hypertonia, phaeochromocytoma, hyperkinetic heart syndrome.
276141
Klingler Karl H.
Offermanns Heribert
Stroman Fritz
Thiemer Klaus
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