C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C07K 14/53 (2006.01) C07K 16/22 (2006.01) C12N 5/10 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2395236
Mono-leucine dependent basolateral sorting signal consisting of the amino acid sequence X1h2X3h4 Lp5p6, wherein: X1 represents a polar amino acid residue or alanine, h2 represents any hydrophobic amino acid residue, X3 represents any amino acid residue, h4 represents any hydrophobic amino acid residue, except leucine and isoleucine L represents a leucine residue, p5 represents any polar amino acid residue, and p6 represents any polar amino acid.
L'invention concerne un signal de tri basolatéral à dépendance mono-leucine représenté par la séquence d'acides aminés X¿1?h¿2?X¿3?h¿4?Lp¿5?p¿6?, dans laquelle X¿1? représente un acide aminé polaire ou un alanine, h¿2? représente un acide aminé hydrophobe quelconque, X¿3? représente un acide aminé quelconque, h¿4? représente un acide aminé hydrophobe quelconque, sauf la leucine et l'isoleucine, L représente une leucine, p¿5? et p¿6? représentent une acide aminé polaire quelconque.
Imhof Beat A.
Wehrlehaller Bernhard M.
Goudreau Gage Dubuc
Universite de Geneve
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